Endogenous proBDNF is a negative regulator of migration of cerebellar granule cells in neonatal mice

@article{Xu2011EndogenousPI,
  title={Endogenous proBDNF is a negative regulator of migration of cerebellar granule cells in neonatal mice},
  author={Zhi-qiang Xu and Ying Sun and Hong-Yun Li and Yoon Lim and Jin-hua Zhong and Xin-Fu Zhou},
  journal={European Journal of Neuroscience},
  year={2011},
  volume={33}
}
The majority of newborn neurons migrate from their birthplace to final destination in the developing brain. Migration of cerebellar granule cells (CGCs) requires multiple factors. Mature brain‐derived neurotrophic factor (BDNF) positively regulates the proliferation, migration, survival and differentiation of CGCs in rodents. However, the role of the BDNF precursor, proBDNF, in neuronal development remains unknown. In this study, we investigated the effect of proBDNF in vivo and in vitro on… 
View on Wiley
ncbi.nlm.nih.gov
52 Citations
Highly Influential Citations
2
Background Citations
25
Methods Citations
4
Results Citations
3

52 Citations

Citation Type

Citation Type

ProBDNF inhibits proliferation, migration and differentiation of mouse neural stem cells
Negative regulation by proBDNF signaling of peripheral neurogenesis in the sensory ganglia of adult rats.
proBDNF inhibits the proliferation and migration of OLN-93 oligodendrocytes
TLDR
It was indicated that proBDNF inhibited OLN-93 cell proliferation in a dose-dependent manner as determined using the MTT assay and BrdU staining and imparts its inhibitory effects on oligodendrocytes through the p75NTR signal pathway.
ProBDNF inhibits collective migration and chemotaxis of rat Schwann cells.
ProBDNF Collapses Neurite Outgrowth of Primary Neurons by Activating RhoA
TLDR
It is shown that proBDNF collapses neurite outgrowth in murine dorsal root ganglion (DRG) neurons and cortical neurons by activating RhoA via the p75 neurotrophin receptor (p75NTR).
proBDNF is a major product of bdnf gene expressed in the perinatal rat cortex.
TLDR
It is found that both proBDNF and mBDNF were expressed abundantly in the rat brainstem, hippocampus and cerebellum between embryonic day 20 and postnatal day 8 and this suggests that proBD NF alone may play an important role in the regulation of naturally occurring cell death during cortical development.
An Aberrant Cerebellar Development in Mice Lacking Matrix Metalloproteinase-3
TLDR
A role for MMP-3 is reported in the histogenesis of the mouse cerebellar cortex and neuronal migration anomalies seem to be caused by an abnormal PC dendritogenesis, which results in reducedPC dendritic trees in the adult cerebellum.
proBDNF Attenuates Hippocampal Neurogenesis and Induces Learning and Memory Deficits in Aged Mice
TLDR
It is concluded that proBDNF attenuates neurogenesis in the hippocampus and induces the deficits in learning and memory functions of aged mice.
BDNF-TrkB and proBDNF-p75NTR/sortilin signaling pathways are involved in mitochondria-mediated neuronal apoptosis in dorsal root ganglia after sciatic nerve transection.
TLDR
The proBDNF signaling pathway is a potential novel therapeutic target for reducing sensory neuron and SGC loss following peripheral nerve injury and induced mitochondrial apoptosis in SGCs and sensory neurons in DRG following SNT.
Inhibitory effects of brain-derived neurotrophic factor precursor on viability and neurite growth of murine hippocampal neurons
TLDR
proBDNF may inhibit the neuronal viability and neurite growth via p75NTR, and it was found that the neurite length in proBDNF group was significantly shorter than that in control group.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 52 REFERENCES
BDNF stimulates migration of cerebellar granule cells.
TLDR
Using time-lapse video microscopy, it is demonstrated that BDNF is acutely motogenic as it stimulates migration of individual granule cells immediately after addition and provides a directional cue promoting migration from the EGL to the internal granule cell layer (IGL).
Axonal growth and fasciculation linked to differential expression of BDNF and NT3 receptors in developing cerebellar granule cells
TLDR
BDNF enhances axonal outgrowth of early granule cells by influencing neurite elongation and NT3 alters the morphology of outgrowth, suggesting that regulation of neurotrophin receptors during cerebellar development is important for the timing and morphology of axonal growth.
Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury
TLDR
The sortilin pathway has distinct roles in pro-neurotrophin–induced apoptotic signaling in pathological conditions, but also in specific stages of neuronal development and aging.
Abnormal Cerebellar Development and Foliation in BDNF −/− Mice Reveals a Role for Neurotrophins in CNS Patterning
ProBDNF Induces Neuronal Apoptosis via Activation of a Receptor Complex of p75NTR and Sortilin
TLDR
In sympathetic neurons coexpressing sortilin and p75NTR, it is found that proBDNF is an apoptotic ligand that induces death at subnanomolar concentrations, suggesting that the neurotrophin family is capable of modulating diverse biological processes via differential processing of the proneurotrophins.
Distinct signaling pathways of precursor BDNF and mature BDNF in cultured cerebellar granule neurons
Differential effects of pro‐BDNF on sensory neurons after sciatic nerve transection in neonatal rats
TLDR
It is concluded that proBDNF may induce the death of axotomized sensory neurons and suppress neuronal addition in the intact DRG in neonatal rats, and the suppression of endogenous proBD NF may protect neurons after neurotrauma.
Cerebellar Granule Cell Migration and the Effects of Alcohol
TLDR
When, where and how granule cells migrate through different cortical layers to reach their final destination are described and mechanisms by which alcohol exposure impairs granule cell migration are revealed.
Proneurotrophin-3 Is a Neuronal Apoptotic Ligand: Evidence for Retrograde-Directed Cell Killing
TLDR
Results raise the intriguing possibility that dysregulation of proneurotrophin processing/release by innervated targets can be deleterious to the neurons projecting to these sites.
The role of neurotrophins in the developing nervous system.
TLDR
A chronological account of the effects of members of the NGF family of neurotrophins on cells of the neural lineage with special reference to the peripheral nervous system is provided.
...
1
2
3
4
5
...