Endogenous presentation of a nuclear antigen on MHC class II by autophagy in the absence of CRM1-mediated nuclear export.

@article{Riedel2008EndogenousPO,
  title={Endogenous presentation of a nuclear antigen on MHC class II by autophagy in the absence of CRM1-mediated nuclear export.},
  author={Alexander Riedel and Falk Nimmerjahn and Stefan Burdach and Uta Behrends and Georg W. Bornkamm and Josef Mautner},
  journal={European journal of immunology},
  year={2008},
  volume={38 8},
  pages={2090-5}
}
Accumulating evidence suggests that intracellular antigens are endogenously presented on MHC class II, but it is still unknown whether antigens within different subcellular compartments are presented with similar efficiency, and via the same or different pathways. We have previously shown that endogenous MHC class II presentation of the cytosolic bacterial antigen neomycin phosphotransferase II (NeoR) is mediated by autophagy. Here, we addressed whether secluding NeoR from this cytoplasmic… CONTINUE READING

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