Endogenous peripheral antinociception in early inflammation is not limited by the number of opioid-containing leukocytes but by opioid receptor expression.

@article{Brack2004EndogenousPA,
  title={Endogenous peripheral antinociception in early inflammation is not limited by the number of opioid-containing leukocytes but by opioid receptor expression.},
  author={Alexander Brack and Heike L Rittner and Halina Machelska and Mohammed A Shaqura and Shaaban A Mousa and Dominika Labuz and Christian Z{\"o}llner and Michael Schaefer and Christoph Stein},
  journal={Pain},
  year={2004},
  volume={108 1-2},
  pages={67-75}
}
Endogenous inhibition of inflammatory pain is mediated by leukocytes that secrete opioid peptides upon exposure to stress (cold water swim stress, CWS) or after local injection of corticotropin releasing factor (CRF). Since in early inflammation few opioid-containing leukocytes are detected and since peripheral opioid-mediated antinociception is low we examined whether antinociception could be augmented by increased recruitment of opioid-containing polymorphonuclear cells (PMN). Rats were… CONTINUE READING
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