Endogenous-peptide-dependent alloreactivity: new scientific insights and clinical implications.

Abstract

T-cell alloreactivity is generated via immune responsiveness directed against allogeneic (allo) human leucocyte antigen (HLA) molecules. Whilst the alloresponse is of extraordinary potency and frequency, it has often been assumed to be less peptide-specific than conventional T-cell reactivity. Recently, several human studies have shown that both… (More)
DOI: 10.1111/tan.12115

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