Endogenous pain control mechanisms: Review and hypothesis

@article{Basbaum1978EndogenousPC,
  title={Endogenous pain control mechanisms: Review and hypothesis},
  author={Allan I. Basbaum and Howard L Fields},
  journal={Annals of Neurology},
  year={1978},
  volume={4}
}
The anatomy, physiology, and pharmacology of an intrinsic neural network that monitors and modulates the activity of pain‐transmitting neurons is reviewed. This system can be activated by opiate administration or by electrical stimulation of discrete brainstem sites. Evidence is presented that its pain‐suppressing action is mediated in part by endogenous opiatelike compounds (endorphins). 
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The theoretical basis and the clinical applications of neurostimulation for the treatment of medically intractable chronic pain are reviewed.
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