Endogenous ornithine in search for CNS functions and therapeutic applications

@article{Seiler1993EndogenousOI,
  title={Endogenous ornithine in search for CNS functions and therapeutic applications},
  author={Nikolaus Seiler and Genevieve Daune-Anglard},
  journal={Metabolic Brain Disease},
  year={1993},
  volume={8},
  pages={151-179}
}
The vertebrate brain has the machinery to transport arginine and ornithine, and to form within nerve endings from these amino acids glutamate and GABA, the major excitatory and inhibitory neurotransmitters. Ornithine aminotransferase is a key enzyme of the Arg -> Om-> Glu -> GABA pathway; the physiological significance of this pathway is still unclear. With 5-fluoromethylornithine, a selective inactivator of ornithine aminotransferase, a tool is in our hands that allows us to study biochemical… CONTINUE READING
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