Endogenous opioids upregulate brain-derived neurotrophic factor mRNA through delta- and micro-opioid receptors independent of antidepressant-like effects.

@article{Zhang2006EndogenousOU,
  title={Endogenous opioids upregulate brain-derived neurotrophic factor mRNA through delta- and micro-opioid receptors independent of antidepressant-like effects.},
  author={Huina Zhang and Mary M Torregrossa and Emily M Jutkiewicz and Yong-Gong Shi and Kenner C. Rice and J. H. Woods and Stanley J. Watson and M C Ko},
  journal={The European journal of neuroscience},
  year={2006},
  volume={23 4},
  pages={984-94}
}
Systemic administration of delta-opioid receptor (DOR) agonists decreases immobility in the forced swim test (FST) and increases brain-derived neurotrophic factor (BDNF) mRNA expression in rats, indicating that DOR agonists may have antidepressant-like effects. The aim of this study was to investigate the effects of central administration of endogenous opioid peptides on behavior in the FST and on brain BDNF mRNA expression in rats. Effects of endogenous opioids were compared with those… CONTINUE READING
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