Endogenous opioids may be involved in idazoxan-induced food intake

@article{Jackson1992EndogenousOM,
  title={Endogenous opioids may be involved in idazoxan-induced food intake},
  author={Helen C. Jackson and Ian J Griffin and David J. Nutt},
  journal={Neuropharmacology},
  year={1992},
  volume={31},
  pages={771-776}
}
The reduction in alcohol intake by the 5-HT1A agonist 8-OH DPAT and its attenuation by the α2 adrenergic antagonist idazoxan correlates with blood glucose levels
TLDR
Results support a role for glucoregulatory processes in serotonergically-mediated changes in alcohol consumption and attenuated the hyperglycemic effect of 8- OH DPAT and completely reversed 8-OH DPAT’s inhibitory effect on alcohol intake.
Preclinical Effects of Opioid Antagonists on Feeding and Appetite
TLDR
The role of general and specific opioid receptor subtype antagonist involvement in the mediation of the palatable and hedonic aspects of food intake and food choice, including ingestion of simple sugars and fats is examined.
Imidazoline Receptor Contributes to Ion and Water Transport across the Intestine of the Eel Acclimated to Sea Water
Abstract Guanabenz, an I2-imidazoline-related compound with high affinity for intestinal membrane of the eel (Kim et al., 1998), enhanced the transepithelial potential difference (PD) and
Novel [3H]Clonidine Binding Sites in the Intestine of the Eel Acclimated to Sea Water
TLDR
Eel intestine may be a good model to elucidate how the IG RS act in the cell and to decide what is the endogenous ligand for the IGRS, since eel intestine contains great amount of IGRS and it responds to guanabenz, an exogenous clonidine derivative.
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The results indicate that α2‐adrenoceptor antagonists may increase water intake by a peripherally mediated mechanism and suggests that the hyperphagic effects of idazoxan may reflect its affinity for a non‐adRenoceptor site, a property not shared by the other α2-antagonists.
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