Endogenous opioids may be involved in idazoxan-induced food intake

  title={Endogenous opioids may be involved in idazoxan-induced food intake},
  author={Helen C. Jackson and Ian J Griffin and David J. Nutt},
The reduction in alcohol intake by the 5-HT1A agonist 8-OH DPAT and its attenuation by the α2 adrenergic antagonist idazoxan correlates with blood glucose levels
Results support a role for glucoregulatory processes in serotonergically-mediated changes in alcohol consumption and attenuated the hyperglycemic effect of 8- OH DPAT and completely reversed 8-OH DPAT’s inhibitory effect on alcohol intake.
Preclinical Effects of Opioid Antagonists on Feeding and Appetite
The role of general and specific opioid receptor subtype antagonist involvement in the mediation of the palatable and hedonic aspects of food intake and food choice, including ingestion of simple sugars and fats is examined.
Imidazoline Receptor Contributes to Ion and Water Transport across the Intestine of the Eel Acclimated to Sea Water
Abstract Guanabenz, an I2-imidazoline-related compound with high affinity for intestinal membrane of the eel (Kim et al., 1998), enhanced the transepithelial potential difference (PD) and
Novel [3H]Clonidine Binding Sites in the Intestine of the Eel Acclimated to Sea Water
Eel intestine may be a good model to elucidate how the IG RS act in the cell and to decide what is the endogenous ligand for the IGRS, since eel intestine contains great amount of IGRS and it responds to guanabenz, an exogenous clonidine derivative.


The effects of idazoxan and other α2‐adrenoceptor antagonists on food and water intake in the rat
The results indicate that α2‐adrenoceptor antagonists may increase water intake by a peripherally mediated mechanism and suggests that the hyperphagic effects of idazoxan may reflect its affinity for a non‐adRenoceptor site, a property not shared by the other α2-antagonists.
An analysis of the effects of systemically administered clonidine on the food and water intake of rats
  • D. Sanger
  • Biology, Medicine
    British journal of pharmacology
  • 1983
The results are consistent with a role for α2‐adrenoceptors in appetite regulation and a competition antagonism of the effect of clonidine in rats, and suggest a need for further research into this area.
Endogenous opioid peptides and regulation of drinking and feeding.
  • L. D. Reid
  • Biology, Psychology
    The American journal of clinical nutrition
  • 1985
A conclusion that opioid peptides are part of a system for regulating ingestion is supported to support a conclusion that Benzodiazepines enhance drinking and eating and apparently interact with opioid systems.