Endogenous opioids, stress induced analgesia, and posttraumatic stress disorder.

@article{Kolk1989EndogenousOS,
  title={Endogenous opioids, stress induced analgesia, and posttraumatic stress disorder.},
  author={Bessel A. van der Kolk and Michael S. Greenberg and Scott P Orr and Roger K. Pitman},
  journal={Psychopharmacology bulletin},
  year={1989},
  volume={25 3},
  pages={417-21}
}
The hypothesis that the animal model of inescapable shock (IES) is an appropriate model for posttraumatic stress disorder (PTSD) predicts that re-exposure to a traumatic stressor will precipitate opioid-mediated stress-induced analgesia in people with PTSD. Eight Vietnam veterans with PTSD and eight matched veterans without PTSD viewed a combat videotape under naloxone and placebo conditions in a randomized double-blind crossover design. In the placebo condition, but not after naloxone, the… CONTINUE READING

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