Endogenous opioid release in the human brain reward system induced by acute amphetamine administration.

Abstract

BACKGROUND We aimed to demonstrate a pharmacologically stimulated endogenous opioid release in the living human brain by evaluating the effects of amphetamine administration on [(11)C]carfentanil binding with positron emission tomography (PET). METHODS Twelve healthy male volunteers underwent [(11)C]carfentanil PET before and 3 hours after a single oral… (More)
DOI: 10.1016/j.biopsych.2012.01.027

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