Endogenous opiates and behavior: 2014

@article{Bodnar2016EndogenousOA,
  title={Endogenous opiates and behavior: 2014},
  author={Richard J Bodnar},
  journal={Peptides},
  year={2016},
  volume={75},
  pages={18-70}
}
  • R. Bodnar
  • Published 31 January 2016
  • Medicine, Psychology
  • Peptides
This paper is the thirty-seventh consecutive installment of the annual review of research concerning the endogenous opioid system. It summarizes papers published during 2014 that studied the behavioral effects of molecular, pharmacological and genetic manipulation of opioid peptides, opioid receptors, opioid agonists and opioid antagonists. The particular topics that continue to be covered include the molecular-biochemical effects and neurochemical localization studies of endogenous opioids and… 
Crosstalk between Opioid and Anti-Opioid Systems: An Overview and Its Possible Therapeutic Significance
TLDR
The phenomenon of crosstalk taking place between opioid and anti-opioid systems at the in vivo pharmacological level is detailed and a cellular and molecular basis for these interactions is proposed.
Treatment with steroid hormones and morphine alters general activity, sexual behavior, and opioid gene expression in female rats.
TLDR
The results suggest that both opioid system activation and sex hormones alter behavioral and molecular patterns in ovariectomized rats within a relatively short period of time.
The Mechanisms Involved in Morphine Addiction: An Overview
TLDR
The present review focuses on major mechanisms which currently are considered as essential in morphine activity and dependence and may be important for further studies.
Discovery of endogenous opioid systems: what it has meant for the clinician's understanding of pain and its treatment
TLDR
2 lines of research have led to new insights into why the endogenous opioid system is so important in terms of evolution, individual survival and day-to-day function, and how important it is to consider opioid medications within the context of these critical natural functions.
Biochemistry of opioid (morphine) receptors: binding, structure and molecular modelling
Morphine is the most widely used compound among narcotic analgesics and remains the gold standard when the effects of other analgetic drugs are compared. The most characteristic effect of morphine is
Epigenetic mechanisms of alcoholism and stress-related disorders.
TLDR
The enzymes responsible for chromatin remodeling have been identified as common molecular mechanisms for the interaction of stress and alcohol and have become promising therapeutic targets to treat or prevent alcoholism and associated emotional disorders.
The modulating effect of glucocorticoids and opioid system on anxiety related behavior in young and adult rats
TLDR
The results show an interactive effect between glucocorticoids and the opioid system on mediating anxiety that can be influenced by age.
Involvement of opioid signaling in food preference and motivation: Studies in laboratory animals.
TLDR
Recent data investigating the effect of opioid receptor antagonists on food preference and effort-related decision making in rats indicate that opioid signaling blockade selectively affects intake of relatively preferred foods, resulting in reduced willingness to exert effort to obtain them.
Ghrelin effects expression of several genes associated with depression-like behavior
TLDR
New evidence is provided about genes, receptors and hormones involved in the antidepressant mechanism/s induced by Ghr in OB animals, suggesting that peptide-effects on depressive-like behavior could be mediated at least in part via AVP.
Cocaine, β-Endorphin, and δ-Opioid Receptors
The current chapter describes the role of β-endorphin and its opioid receptor type delta (DOR) in cocaine reward, reinforcement, and craving, and in new studies of relapse to cocaine usage. The
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 1,226 REFERENCES
The Oxytocin Analogue Carbetocin Prevents Emotional Impairment and Stress-Induced Reinstatement of Opioid-Seeking in Morphine-Abstinent Mice
The main challenge in treating opioid addicts is to maintain abstinence due to the affective consequences associated with withdrawal which may trigger relapse. Emerging evidence suggests a role of
Significance of neuronal cytochrome P450 activity in opioid-mediated stress-induced analgesia
TLDR
This work is the first to show that some forms of opioid-mediated stress-induced analgesia require brain neuronal P450 activity, and shows a critical role for neuronal P 450s in this response.
Relationship Between Endogenous Opioid Function and Opioid Analgesic Adverse Effects
TLDR
No consistent relationships were observed between endogenous opioid function and morphine-related adverse effects, in stark contrast to the previous observation of strong relationships between elevated endogenous opioids function and smaller morphine analgesic effects.
Withdrawal syndrome caused by naltrexone in opioid abusers
TLDR
Emergency physicians should be aware of the potential for severe agitation from naltrexone-precipitated hyperacute withdrawal and its appropriate management and be warned about misuse of nALTrexone.
Epigenetic regulation of opioid-induced hyperalgesia, dependence, and tolerance in mice.
TLDR
It is indicated that epigenetic mechanisms play a crucial role in opioid-induced long-lasting neuroplasticity and new strategies to limit opioid abuse potential and increase the value of these drugs as analgesics are suggested.
Treatment with steroid hormones and morphine alters general activity, sexual behavior, and opioid gene expression in female rats.
TLDR
The results suggest that both opioid system activation and sex hormones alter behavioral and molecular patterns in ovariectomized rats within a relatively short period of time.
The effect of vitamin C on morphine self-administration in rats
TLDR
The chronic administration of Ascorbic acid may prevent the development of tolerance and physical dependence on morphine self-administration via the glutamatergic system.
Role of phosphodiesterase inhibitor Ibudilast in morphine-induced hippocampal injury
TLDR
Ibudilast can be used for controlling and treatment of morphine-induced CNS inflammations or traumatic conditions, and data showed that IbUDilast suppresses IL-1 β expression significantly more than β-FNA.
Spironolactone decreases the somatic signs of opiate withdrawal by blocking the mineralocorticoid receptors (MR).
TLDR
The results suggest that somatic signs of opiate withdrawal are modulated by MR signaling, however, blockade of MR did not significantly alter the brain stress system response to morphine withdrawal.
Cardiac adverse effects of naloxone-precipitated morphine withdrawal on right ventricle: role of corticotropin-releasing factor (CRF) 1 receptor.
TLDR
Results support the idea that cardiac sympathetic pathways are activated in response to naloxone-precipitated morphine withdrawal suggesting that treatment with a CRF1 receptor antagonist before morphine withdrawal would prevent the development of stress-induced behavioural and autonomic dysfunction in opioid addicts.
...
1
2
3
4
5
...