Endogenous oocyte antigens are required for rapid induction and progression of autoimmune ovarian disease following day-3 thymectomy.

@article{Alard2001EndogenousOA,
  title={Endogenous oocyte antigens are required for rapid induction and progression of autoimmune ovarian disease following day-3 thymectomy.},
  author={Pascale Alard and Claire Thompson and Sally S. Agersborg and Jayant Thatte and Yulius Yulianto Setiady and Eileen Teresa Samy and Kenneth S Tung},
  journal={Journal of immunology},
  year={2001},
  volume={166 7},
  pages={4363-9}
}
Female (C57BL/6xA/J)F(1) mice undergoing thymectomy on day 3 after birth (d3tx) developed autoimmune ovarian disease (AOD) and autoimmune disease of the lacrimal gland. As both were prevented by normal adult CD25(+) T cells, regulatory T cell depletion is responsible for d3tx diseases. AOD began as oophoritis at 3 wk. By 4 wk, AOD progressed to ovarian atrophy with autoantibody response against multiple oocyte Ag of early ontogeny. The requirement for immunogenic endogenous ovarian Ag was… CONTINUE READING

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