Endogenous nociceptin/orphanin-FQ in the dorsal hippocampus facilitates despair-related behavior.

Abstract

Nociceptin/orphanin-FQ (N/OFQ) peptide and its receptor (NOP: N/OFQ opioid peptide receptor) are highly expressed in the hippocampus, but their functional role remains poorly understood. We recently showed that hippocampal N/OFQ inhibits learning and memory abilities in mice. Here, we investigated whether the endogenous peptide also regulated emotional… (More)
DOI: 10.1002/hipo.20760

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