Endogenous nitric oxide suppresses rat myometrial connexin 43 gap junction protein expression during pregnancy.

@article{Sladek1999EndogenousNO,
  title={Endogenous nitric oxide suppresses rat myometrial connexin 43 gap junction protein expression during pregnancy.},
  author={Stefan Sladek and A Westerhausen-Larson and James M Roberts},
  journal={Biology of reproduction},
  year={1999},
  volume={61 1},
  pages={8-13}
}
Nitric oxide (NO) synthase (NOS) is active in the gravid uterus, and its activity decreases prior to the onset of parturition. We tested the hypothesis that NO helps maintain uterine quiescence by suppressing the expression of genes necessary for parturition. Pregnant rats (18 days gestation) were treated with inducible NOS (iNOS) inhibitor N-iminoethyl-L-lysine (NIL) or endothelial NOS inhibitor nitro-L-arginine methyl ester (L-NAME); 24 h later, uteri were analyzed for myometrial connexin 43… CONTINUE READING