Endogenous nitric oxide mechanisms mediate the stretch dependence of Ca2+ release in cardiomyocytes

  title={Endogenous nitric oxide mechanisms mediate the stretch dependence of Ca2+ release in cardiomyocytes},
  author={Mart{\'i}n G. Vila Petroff and Suhn Hee Kim and Salvatore Pepe and Chantal Dessy and Eduardo Marb{\'a}n and Jean-Luc Balligand and Steven J. Sollott},
  journal={Nature Cell Biology},
Stretching of cardiac muscle modulates contraction through the enhancement of the Ca2+ transient, but how this occurs is still not known. We found that stretching of myocytes modulates the elementary Ca2+ release process from ryanodine-receptor Ca2+-release channels (RyRCs), Ca2+ sparks and the electrically stimulated Ca2+ transient. Stretching induces PtdIns-3-OH kinase (PI(3)K)-dependent phosphorylation of both Akt and the endothelial isoform of nitric oxide synthase (NOS), nitric oxide (NO… CONTINUE READING
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Upregulation of β3-adrenoceptors and altered contractile response to inotropic amines in human failing myocardium

  • S Moniotte
  • Circulation 103,
  • 2001

Biology and Pathobiology (ed

  • J. L. Balligand, O. Feron, Kelly, R. A. in Nitric Oxide
  • Ignarro, L.) 585–607
  • 2000

G-dependent phosphoinositide 3-kinase activation in hearts with in vivo pressure overload hypertrophy

  • S. V. Naga Prasad, G. Esposito, L. Mao, W. J. Koch, H. A. Rockman
  • J. Biol
  • 2000

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