Endogenous nitric oxide mechanisms mediate the stretch dependence of Ca2+ release in cardiomyocytes

@article{Petroff2001EndogenousNO,
  title={Endogenous nitric oxide mechanisms mediate the stretch dependence of Ca2+ release in cardiomyocytes},
  author={Mart{\'i}n G. Vila Petroff and Suhn Hee Kim and Salvatore Pepe and Chantal Dessy and Eduardo Marb{\'a}n and Jean-Luc Balligand and Steven J. Sollott},
  journal={Nature Cell Biology},
  year={2001},
  volume={3},
  pages={867-873}
}
Stretching of cardiac muscle modulates contraction through the enhancement of the Ca2+ transient, but how this occurs is still not known. We found that stretching of myocytes modulates the elementary Ca2+ release process from ryanodine-receptor Ca2+-release channels (RyRCs), Ca2+ sparks and the electrically stimulated Ca2+ transient. Stretching induces PtdIns-3-OH kinase (PI(3)K)-dependent phosphorylation of both Akt and the endothelial isoform of nitric oxide synthase (NOS), nitric oxide (NO… CONTINUE READING
Highly Influential
This paper has highly influenced 12 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 100 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 55 references

Upregulation of β3-adrenoceptors and altered contractile response to inotropic amines in human failing myocardium

  • S Moniotte
  • Circulation 103,
  • 2001

Biology and Pathobiology (ed

  • J. L. Balligand, O. Feron, Kelly, R. A. in Nitric Oxide
  • Ignarro, L.) 585–607
  • 2000

G-dependent phosphoinositide 3-kinase activation in hearts with in vivo pressure overload hypertrophy

  • S. V. Naga Prasad, G. Esposito, L. Mao, W. J. Koch, H. A. Rockman
  • J. Biol
  • 2000

Similar Papers

Loading similar papers…