Endogenous nitric oxide is responsible for the early loss of P450 in cultured rat hepatocytes.

Abstract

Loss of P450 during the early hours of monolayer formation is known to be the more serious limitation of primary cultured hepatocytes as an adequate model for the study of drug metabolism, toxicity and P450 induction. This study reports that endogenous nitric oxide (NO) formation is activated shortly after isolation by the classical collagenase-based liver… (More)

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