Endogenous nitric oxide as a probable modulator of pulmonary circulation and hypoxic pressor response in vivo.

@article{Persson1990EndogenousNO,
  title={Endogenous nitric oxide as a probable modulator of pulmonary circulation and hypoxic pressor response in vivo.},
  author={Margareta Persson and Lars E. Gustafsson and Nils Peter Wiklund and Salvador Moncada and Per Hedqvist},
  journal={Acta physiologica Scandinavica},
  year={1990},
  volume={140 4},
  pages={449-57}
}
The objective of this study was to investigate the role of endogenous nitric oxide, formed from L-arginine, in the regulation of pulmonary circulation in vivo, with special reference to the hypoxic pressor response. In artificially ventilated open-chest rabbits, pulmonary vascular resistance at normoxic ventilation (FIO2 = 21%) was 78 +/- 16 cmH2O ml-1 min 1000-1 (mRUL). Hypoxic ventilation (FIO2 = 10%) increased pulmonary vascular resistance to 117 +/- 17 mRUL. N omega-nitro-L-arginine… CONTINUE READING

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