Endogenous nitric oxide acts as a natural antithrombotic agent in vivo by inhibiting platelet aggregation in the pulmonary vasculature.

@article{Emerson1999EndogenousNO,
  title={Endogenous nitric oxide acts as a natural antithrombotic agent in vivo by inhibiting platelet aggregation in the pulmonary vasculature.},
  author={Michael Emerson and Stefania Momi and William George Paul and Paolo Alberti and Clive P Page and Paolo Gresele},
  journal={Thrombosis and haemostasis},
  year={1999},
  volume={81 6},
  pages={961-6}
}
Nitric oxide (NO) is a powerful vasodilator and an inhibitor of platelet aggregation in vitro. While the ability of NO to modulate vascular tone in vivo has been proven, only a few studies have assessed its platelet inhibitory activity in vivo. We have employed two complementary animal models of pulmonary platelet thromboembolism to assess the antithrombotic activity of endogenous NO in vivo. The inhibition of nitric oxide synthase (NOS) by L-NAME significantly potentiated while the… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 21 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 31 references

Evidence that endogenous nitric oxide modulates plasma fibrinogen levels in the rat.

British journal of pharmacology • 1996
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…