Endogenous neurosteroids regulate GABAA receptors through two discrete transmembrane sites

  title={Endogenous neurosteroids regulate GABAA receptors through two discrete transmembrane sites},
  author={A. Hosie and M. E. Wilkins and H. M. Silva and T. Smart},
  • A. Hosie, M. E. Wilkins, +1 author T. Smart
  • Published 2006
  • Biology, Medicine
  • Nature
  • Inhibitory neurotransmission mediated by GABAA receptors can be modulated by the endogenous neurosteroids, allopregnanolone and tetrahydro-deoxycorticosterone. Neurosteroids are synthesized de novo in the brain during stress, pregnancyand after ethanol consumption, and disrupted steroid regulation of GABAergic transmission is strongly implicated in several debilitating conditions such as panic disorder, major depression, schizophrenia, alcohol dependence and catamenial epilepsy. Determining how… CONTINUE READING
    626 Citations
    Inhibitory neurosteroids and the GABAA receptor.
    • 22
    Physiological roles of endogenous neurosteroids at α2 subunit-containing GABAA receptors
    • Highly Influenced
    • PDF
    Neurosteroids promote phosphorylation and membrane insertion of extrasynaptic GABAA receptors
    • 66
    • PDF
    Brain neurosteroids are natural anxiolytics targeting α2 subunit γ-aminobutyric acid type-A receptors
    • 3
    • PDF
    Neurosteroid modulation of synaptic and extrasynaptic GABA(A) receptors.
    • 185
    Multiple roles for the first transmembrane domain of GABAA receptor subunits in neurosteroid modulation and spontaneous channel activity
    • 12
    • Highly Influenced
    Structural basis for GABAA receptor potentiation by neurosteroids
    • 82
    • PDF
    GABA-A Receptors Mediate Tonic Inhibition and Neurosteroid Sensitivity in the Brain.
    • D. Reddy
    • Chemistry, Medicine
    • Vitamins and hormones
    • 2018
    • 12


    Neurosteroid Access to the GABAA Receptor
    • 140
    • PDF
    Neurosteroids: endogenous regulators of the GABAA receptor
    • 941
    Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by δ subunit-containing GABAA receptors
    • 732
    • PDF
    Neurosteroid Biosynthesis in the Human Brain and Its Clinical Implications
    • 192