Endogenous neurosteroids regulate GABAA receptors through two discrete transmembrane sites

@article{Hosie2006EndogenousNR,
  title={Endogenous neurosteroids regulate GABAA receptors through two discrete transmembrane sites},
  author={Alastair M. Hosie and Megan E. Wilkins and Helena da Silva and Trevor G. Smart},
  journal={Nature},
  year={2006},
  volume={444},
  pages={486-489}
}
Inhibitory neurotransmission mediated by GABAA receptors can be modulated by the endogenous neurosteroids, allopregnanolone and tetrahydro-deoxycorticosterone. Neurosteroids are synthesized de novo in the brain during stress, pregnancyand after ethanol consumption, and disrupted steroid regulation of GABAergic transmission is strongly implicated in several debilitating conditions such as panic disorder, major depression, schizophrenia, alcohol dependence and catamenial epilepsy. Determining how… 
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