Endogenous neurosteroids regulate GABAA receptors through two discrete transmembrane sites

@article{Hosie2006EndogenousNR,
  title={Endogenous neurosteroids regulate GABAA receptors through two discrete transmembrane sites},
  author={A. Hosie and M. E. Wilkins and H. M. Silva and T. Smart},
  journal={Nature},
  year={2006},
  volume={444},
  pages={486-489}
}
  • A. Hosie, M. E. Wilkins, +1 author T. Smart
  • Published 2006
  • Biology, Medicine
  • Nature
  • Inhibitory neurotransmission mediated by GABAA receptors can be modulated by the endogenous neurosteroids, allopregnanolone and tetrahydro-deoxycorticosterone. Neurosteroids are synthesized de novo in the brain during stress, pregnancyand after ethanol consumption, and disrupted steroid regulation of GABAergic transmission is strongly implicated in several debilitating conditions such as panic disorder, major depression, schizophrenia, alcohol dependence and catamenial epilepsy. Determining how… CONTINUE READING
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    References

    SHOWING 1-10 OF 31 REFERENCES
    Neurosteroid Access to the GABAA Receptor
    • 140
    • PDF
    Neurosteroids: endogenous regulators of the GABAA receptor
    • 941
    Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by δ subunit-containing GABAA receptors
    • 732
    • PDF
    Neurosteroid Biosynthesis in the Human Brain and Its Clinical Implications
    • 192