Endogenous myelin basic protein is presented in the periphery by both dendritic cells and resting B cells with different functional consequences.

@article{Seamons2006EndogenousMB,
  title={Endogenous myelin basic protein is presented in the periphery by both dendritic cells and resting B cells with different functional consequences.},
  author={Audrey Seamons and Antoine Perchellet and Joan M. Goverman},
  journal={Journal of immunology},
  year={2006},
  volume={177 4},
  pages={2097-106}
}
Multiple sclerosis is an inflammatory disease believed to be triggered by erroneous activation of self-reactive T cells specific for myelin proteins such as myelin basic protein (MBP). Inflammation is limited to the CNS, suggesting that the myelin-specific T cells encounter their Ags only after they cross the blood-brain barrier. However, our previous… CONTINUE READING