Endogenous morphine and nitric oxide coupled regulation of mitochondrial processes.

  title={Endogenous morphine and nitric oxide coupled regulation of mitochondrial processes.},
  author={Richard M. Kream and G B Stefano},
  journal={Medical science monitor : international medical journal of experimental and clinical research},
  volume={15 12},
The widespread expression of morphine by plants, invertebrate and vertebrate cells/organ systems strongly indicates a high level of evolutionary conservation of morphine and related morphinan alkaloids as essential chemical factors required for normal growth and development. The prototype catecholamine dopamine (DA) serves as an essential chemical intermediate in morphine biosynthesis both in plants and animals. We surmise primordial, multi-potential cell types, before the emergence of… CONTINUE READING
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