Endogenous mitochondrial oxidative stress: neurodegeneration, proteomic analysis, specific respiratory chain defects, and efficacious antioxidant therapy in superoxide dismutase 2 null mice.

@article{Hinerfeld2004EndogenousMO,
  title={Endogenous mitochondrial oxidative stress: neurodegeneration, proteomic analysis, specific respiratory chain defects, and efficacious antioxidant therapy in superoxide dismutase 2 null mice.},
  author={Douglas Hinerfeld and Mathew D Traini and Ron P. Weinberger and Bruce Cochran and Susan R. Doctrow and Jenny L. Harry and Simon Melov},
  journal={Journal of neurochemistry},
  year={2004},
  volume={88 3},
  pages={657-67}
}
Oxidative stress and mitochondrial dysfunction have been linked to neurodegenerative disorders such as Parkinson's and Alzheimer's disease. However, it is not yet understood how endogenous mitochondrial oxidative stress may result in mitochondrial dysfunction. Most prior studies have tested oxidative stress paradigms in mitochondria through either chemical inhibition of specific components of the respiratory chain, or adding an exogenous insult such as hydrogen peroxide or paraquat to directly… CONTINUE READING
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