Endogenous microRNAs induced by heat-shock reduce myocardial infarction following ischemia-reperfusion in mice.

@article{Yin2008EndogenousMI,
  title={Endogenous microRNAs induced by heat-shock reduce myocardial infarction following ischemia-reperfusion in mice.},
  author={Chang Yen Yin and Xiaoyin Wang and Rakesh C. Kukreja},
  journal={FEBS letters},
  year={2008},
  volume={582 30},
  pages={4137-42}
}
We investigated the role of microRNAs (miRNA) in protection against ischemia/reperfusion (I/R) injury in heart. Mice subjected to cytoprotective heat-shock (HS) showed a significant increase of miRNA-1, miRNA-21 and miRNA-24 in the heart. miRNAs isolated from HS mice and injected into non-HS mice significantly reduced infarct size after I/R injury, which was associated with the inhibition of pro-apoptotic genes and increase in anti-apoptotic genes. Chemically synthesized miRNA-21 also reduced… CONTINUE READING

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