Endogenous microRNA regulation suppresses transgene expression in hematopoietic lineages and enables stable gene transfer

@article{Brown2006EndogenousMR,
  title={Endogenous microRNA regulation suppresses transgene expression in hematopoietic lineages and enables stable gene transfer},
  author={Brian D Brown and Mary Anna Venneri and Anna Zingale and Lucia Sergi Sergi and Luigi Naldini},
  journal={Nature Medicine},
  year={2006},
  volume={12},
  pages={585-591}
}
MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression by repressing translation of target cellular transcripts. Increasing evidence indicates that miRNAs have distinct expression profiles and play crucial roles in numerous cellular processes, although the extent of miRNA regulation is not well known. By challenging mice with lentiviral vectors encoding target sequences of endogenous miRNAs, we show the efficiency of miRNAs in sharply segregating gene expression among… Expand
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