Endogenous memory CD8 T cells directly mediate cardiac allograft rejection.

@article{Su2014EndogenousMC,
  title={Endogenous memory CD8 T cells directly mediate cardiac allograft rejection.},
  author={Charles A. Su and Shinichiro Iida and Tomoyuki Abe and R. L. Heckaman Mark D. Fairchild},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  year={2014},
  volume={14 3},
  pages={
          568-79
        }
}
Differences in levels of environmentally induced memory T cells that cross-react with donor MHC molecules are postulated to account for the efficacy of allograft tolerance-inducing strategies in rodents versus their failure in nonhuman primates and human transplant patients. Strategies to study the impact of donor-reactive memory T cells on allografts in rodents have relied on the pretransplant induction of memory T cells cross-reactive with donor allogeneic MHC molecules through recipient… CONTINUE READING
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