Endogenous ligands of PPAR-gamma reduce the liver injury in haemorrhagic shock.

@article{Collin2004EndogenousLO,
  title={Endogenous ligands of PPAR-gamma reduce the liver injury in haemorrhagic shock.},
  author={Marika Collin and Maha Abdelrahman and Christoph Thiemermann},
  journal={European journal of pharmacology},
  year={2004},
  volume={486 2},
  pages={233-5}
}
We demonstrate here for the first time that the novel, potent peroxisome proliferator-activated receptor (PPAR)-gamma antagonist GW9662 (2-chloro-5-nitrobenzanilide) augments the degree of liver injury associated with haemorrhagic (haemorrhage for 90 min and resuscitation for 4 h), but not endotoxic (6 mg/kg E. coli endotoxin i.v. for 6 h) shock in the… CONTINUE READING