Endogenous leukotriene D4 formation during anaphylactic shock in the guinea pig.

  title={Endogenous leukotriene D4 formation during anaphylactic shock in the guinea pig.},
  author={Andrea Keppler and Lars Orning and Kerstin Bernstr{\"o}m and Sven Hammarstr{\"o}m},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={84 16},
Experiments on the metabolism and excretion of i.v. administered selectively labeled [3H8]leukotriene C4 in bile duct-cannulated guinea pigs indicated predominantly biliary excretion of tritium. The major leukotriene metabolite in bile was identified as leukotriene D4. By monitoring leukotriene excretion radioimmunochromatographically, it was shown that guinea pigs suffering from anaphylactic shock produce leukotriene D4 endogenously. Immunological challenge of animals sensitized to ovalbumin… Expand
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