Endogenous kynurenines as targets for drug discovery and development

  title={Endogenous kynurenines as targets for drug discovery and development},
  author={Trevor W Stone and L. Gail Darlington},
  journal={Nature Reviews Drug Discovery},
The kynurenine pathway is the main pathway for tryptophan metabolism. It generates compounds that can modulate activity at glutamate receptors and possibly nicotinic receptors, in addition to some as-yet-unidentified sites. The pathway is in a unique position to regulate other aspects of the metabolism of tryptophan to neuroactive compounds, and also seems to be a key factor in the communication between the nervous and immune systems. It also has potentially important roles in the regulation of… CONTINUE READING
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The development and therapeutic potential of kynurenic acid and kynurenine derivatives for CNS neuroprotection

  • T. W. Stone
  • Trends Pharmacol. Sci
  • 2000
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  • K Dikranian
  • Neurobiol. Disease
  • 2001

Elevated CSF quinolinic acid levels are associated with region-specific cerebral volume loss in HIV infection

  • Heyes, P M.
  • Brain Res
  • 2001

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