Endogenous kynurenines as targets for drug discovery and development

@article{Stone2002EndogenousKA,
  title={Endogenous kynurenines as targets for drug discovery and development},
  author={Trevor W Stone and L. Gail Darlington},
  journal={Nature Reviews Drug Discovery},
  year={2002},
  volume={1},
  pages={609-620}
}
The kynurenine pathway is the main pathway for tryptophan metabolism. It generates compounds that can modulate activity at glutamate receptors and possibly nicotinic receptors, in addition to some as-yet-unidentified sites. The pathway is in a unique position to regulate other aspects of the metabolism of tryptophan to neuroactive compounds, and also seems to be a key factor in the communication between the nervous and immune systems. It also has potentially important roles in the regulation of… CONTINUE READING
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