Endogenous interleukin-6 enhances the renal injury, dysfunction, and inflammation caused by ischemia/reperfusion.

@article{Patel2005EndogenousIE,
  title={Endogenous interleukin-6 enhances the renal injury, dysfunction, and inflammation caused by ischemia/reperfusion.},
  author={Nimesh S. A. Patel and Prabal Kumar Chatterjee and Rosanna di Paola and Emanuela Mazzon and Domenico Britti and Angelina De Sarro and Salvatore Cuzzocrea and Christoph Thiemermann},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2005},
  volume={312 3},
  pages={1170-8}
}
Here, we investigate the effects of renal ischemia/reperfusion (I/R) on the degree of renal injury, dysfunction, and inflammation in interleukin (IL)-6 knockout (IL-6(-/-)) mice and mice administered a monoclonal antibody against IL-6. IL-6(-/-) mice were subjected to bilateral renal artery occlusion (30 min) and reperfusion (24 h). At the end of experiments, indicators and markers of renal dysfunction, injury, and inflammation were measured. Kidneys were used for histological evaluation of… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 64 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 52 references

loss caused by estrogen depletion

  • H Rabb, YM O’Meara, P Maderna, P Coleman, HR Brady
  • EMBO (Eur Mol Biol Organ) J
  • 1997
Highly Influential
5 Excerpts

Plasma cytokine levels

  • S Soroko, S Freedman, K Becker, D Spratt
  • 2004

Similar Papers

Loading similar papers…