Endogenous interferon-gamma is required for efficient skeletal muscle regeneration.

  title={Endogenous interferon-gamma is required for efficient skeletal muscle regeneration.},
  author={Ming ‐ Jun Cheng and Mai-Huong Thi Nguyen and Giamila Fantuzzi and Timothy J Koh},
  journal={American journal of physiology. Cell physiology},
  volume={294 5},
The inflammatory response is thought to play important roles in tissue healing. The hypothesis of this study was that the inflammatory cytokine interferon (IFN)-gamma is produced endogenously following skeletal muscle injury and promotes efficient healing. We show that IFN-gamma is expressed at both mRNA and protein levels in skeletal muscle following injury, and that the time course of IFN-gamma expression correlated with the accumulation of macrophages, T-cells, and natural killer cells, as… CONTINUE READING

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