Endogenous hypometabolic-hypothermic factors and their possible application to life in the cold

@article{Kramarova2009EndogenousHF,
  title={Endogenous hypometabolic-hypothermic factors and their possible application to life in the cold},
  author={L. Kramarova and R. Ziganshin and E. Gakhova},
  journal={Russian Journal of Bioorganic Chemistry},
  year={2009},
  volume={35},
  pages={538-548}
}
Mammalian hibernation is a natural model of tolerance of oragnisms, its tissues and cells to hypometabolism, hypothermia, hypoxia, bradycardia, and long-term hypophagia. Here, we review recent advances in the isolation and identification of some natural endogenous regulators from hibernating and cold-adapted animals: proteins, peptides, and nonpeptide substances. We also discuss the employment of molecular, biochemical, and physiological mechanisms of natural hypobiosis in ecology, cryomedicine… Expand

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