Endogenous hormones and ovarian cancer: epidemiology and current hypotheses.

  title={Endogenous hormones and ovarian cancer: epidemiology and current hypotheses.},
  author={Annekatrin Lukanova and Rudolf Kaaks},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  volume={14 1},
The effect of major epidemiologic risk factors for ovarian cancer has been reviewed in the light of several hormonal hypotheses, including the gonadotropin, androgens, progesterone, estrogens, insulin-like growth factor-I, and insulin hypotheses. The role of inclusion cyst formation and Mullerian epithelium differentiation in the pathology of the disease are also briefly outlined. Although based on limited data, the observed tendency in current evidence suggests possible etiologic roles for… CONTINUE READING


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