Endogenous histamine stimulates ischemically sensitive abdominal visceral afferents through H1 receptors.

@article{Fu1997EndogenousHS,
  title={Endogenous histamine stimulates ischemically sensitive abdominal visceral afferents through H1 receptors.},
  author={L W Fu and Hui-Lin Pan and John C. Longhurst},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={1997},
  volume={273 6},
  pages={H2726-H2737}
}
  • L. Fu, H. Pan, J. Longhurst
  • Published 1997
  • Biology, Medicine, Chemistry
  • American journal of physiology. Heart and circulatory physiology
Abdominal ischemia stimulates sympathetic visceral afferents to reflexly activate the cardiovascular system. We have shown previously that topical application of histamine (HA) to the gastric wall causes reflex cardiovascular responses and have documented increased histamine concentrations in intestinal lymph and portal venous plasma during brief abdominal ischemia. In the present study, we hypothesized that histamine produced during ischemia activates ischemically sensitive C-fiber afferents… 

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