Endogenous glucocorticoids cause thymus atrophy but are protective during acute Trypanosoma cruzi infection.

  title={Endogenous glucocorticoids cause thymus atrophy but are protective during acute Trypanosoma cruzi infection.},
  author={Eduardo Angel Roggero and Ana R. P{\'e}rez and Maximiliano Tamae-Kakazu and Isabel M. Piazz{\'o}n and Irene Nepomnaschy and Hugo Oscar Besedovsky and Oscar Adelmo Bottasso and Adriana del Rey},
  journal={The Journal of endocrinology},
  volume={190 2},
The cytokine-mediated stimulation of the hypothalamus-pituitary-adrenal (HPA) axis is relevant for survival during bacterial endotoxemia and certain viral infections. However, only limited information is available regarding the effects of endogenous glucocorticoids on parasite diseases. We have studied this issue using, as a model, C57Bl/6 and Balb/c mice infected with Trypanosoma cruzi, the causal agent of Chagas' disease. These two mouse strains differ in the susceptibility to infection with… CONTINUE READING
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