Endogenous glucocorticoid receptor signaling drives rhythmic changes in human T-cell subset numbers and the expression of the chemokine receptor CXCR4.

@article{Besedovsky2014EndogenousGR,
  title={Endogenous glucocorticoid receptor signaling drives rhythmic changes in human T-cell subset numbers and the expression of the chemokine receptor CXCR4.},
  author={Luciana Besedovsky and Jan Born and Tanja Lange},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2014},
  volume={28 1},
  pages={67-75}
}
In humans, numbers of circulating naive T cells strongly decline in the morning, which was suggested to be mediated by cortisol, inducing a CXCR4 up-regulation with a subsequent extravasation of the cells. As a systematic evaluation of this assumption is lacking, we investigated in two human placebo-controlled studies the effects of the glucocorticoid receptor (GR) antagonist mifepristone (200 mg orally at 23:00) and of suppressing endogenous cortisol with metyrapone (1 g orally at 04:00) on… CONTINUE READING
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