Endogenous generation and protective effects of nitro-fatty acids in a murine model of focal cardiac ischaemia and reperfusion.

@article{Rudolph2010EndogenousGA,
  title={Endogenous generation and protective effects of nitro-fatty acids in a murine model of focal cardiac ischaemia and reperfusion.},
  author={Volker Rudolph and Tanja K. Rudolph and Francisco J Schopfer and Gustavo Bonacci and Steven R. Woodcock and Marsha P Cole and Paul R. S. Baker and Ravi S. Ramani and Bruce A. Freeman},
  journal={Cardiovascular research},
  year={2010},
  volume={85 1},
  pages={155-66}
}
AIMS Nitrated fatty acids (NO(2)-FA) have been identified as endogenous anti-inflammatory signalling mediators generated by oxidative inflammatory reactions. Herein the in vivo generation of nitro-oleic acid (OA-NO(2)) and nitro-linoleic acid (LNO(2)) was measured in a murine model of myocardial ischaemia and reperfusion (I/R) and the effect of exogenous administration of OA-NO(2) on I/R injury was evaluated. METHODS AND RESULTS In C57/BL6 mice subjected to 30 min of coronary artery ligation… CONTINUE READING
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