Endogenous fructose production and fructokinase activation mediate renal injury in diabetic nephropathy.

@article{Lanaspa2014EndogenousFP,
  title={Endogenous fructose production and fructokinase activation mediate renal injury in diabetic nephropathy.},
  author={Miguel A Lanaspa and Takuji Ishimoto and Christina M. Cicerchi and Yoshifuru Tamura and Carlos A. Roncal-Jimenez and Wei Chen and Katsuyuki Tanabe and Ana Andr{\'e}s-Hernando and David J Orlicky and Esteban Finol and Shinichiro Inaba and Nanxing Li and Christopher J. Rivard and Tomoki Kosugi and L Gabriela S{\'a}nchez-Lozada and J. Mark Petrash and Yuri Y. Sautin and A. Ahsan Ejaz and Wataru Kitagawa and Gabriela E. Garcia and David T. Bonthron and Aruna Asipu and Christine P Diggle and Bernardo Rodriguez-Iturbe and Takahiko Nakagawa and Richard J Johnson},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2014},
  volume={25 11},
  pages={2526-38}
}
Diabetes is associated with activation of the polyol pathway, in which glucose is converted to sorbitol by aldose reductase. Previous studies focused on the role of sorbitol in mediating diabetic complications. However, in the proximal tubule, sorbitol can be converted to fructose, which is then metabolized largely by fructokinase, also known as ketohexokinase, leading to ATP depletion, proinflammatory cytokine expression, and oxidative stress. We and others recently identified a potential… CONTINUE READING