Endogenous fragment of hemoglobin, neokyotorphin, as cell growth factor

@article{Blishchenko2001EndogenousFO,
  title={Endogenous fragment of hemoglobin, neokyotorphin, as cell growth factor },
  author={Elena Yu. Blishchenko and Olga A. Kalinina and O V Sazonova and Sergei V. Khaidukov and Vadim Tikhonovich Ivanov},
  journal={Peptides},
  year={2001},
  volume={22},
  pages={1999-2008}
}
It is shown that neokyotorphin (the alpha-globin fragment 137-141) stimulates proliferation of normal cells (murine embryonic fibroblasts, red bone marrow and spleen cells) and tumor cells (murine melanoma and transformed fibroblasts L929) in the absence or in the presence of fetal bovine serum. In contrast to serum deprivation conditions, the ability to potentiate L929 cell growth in the presence of fetal serum is strongly cell density dependent. The peptide also enhances the viability of L929… CONTINUE READING
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