Endogenous ephrinB2 mediates colon-urethra cross-organ sensitization via Src kinase-dependent tyrosine phosphorylation of NR2B.

@article{Peng2010EndogenousEM,
  title={Endogenous ephrinB2 mediates colon-urethra cross-organ sensitization via Src kinase-dependent tyrosine phosphorylation of NR2B.},
  author={Hsien-Yu Peng and Gin-Den Chen and Cheng-Hung Lai and K R Tung and J F Chang and T Lin},
  journal={American journal of physiology. Renal physiology},
  year={2010},
  volume={298 1},
  pages={F109-17}
}
Recently, the role of EphB receptor (EphBR) tyrosine kinase and their ephrinB ligands in spinal pain-related neural plasticity has been identified. To test whether Src-family non-receptor tyrosine kinase-dependent glutamatergic N-methyl-d-aspartate receptor (NMDAR) NR2B subunit phosphorylation underlies lumbosacral spinal EphBR activation to mediate cross-organ sensitization between the colon and the urethra, external urethra sphincter electromyogram activity evoked by pelvic nerve stimulation… CONTINUE READING

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