Endogenous endothelin in a rat model of acute colonic mucosal injury.

  title={Endogenous endothelin in a rat model of acute colonic mucosal injury.},
  author={Masaru Sugimachi and Tatsuya Kiyohara and Yoko Murayama and Takayuki Minami and Yoshiji Miyazaki and J Miyagawa and Yasuhisa Shinomura and Yuji Matsuzawa},
  journal={Journal of gastroenterology and hepatology},
  volume={15 10},
BACKGROUND Endothelin (ET) is involved in various biologic activities in non-vascular and vascular tissues. While ET has some significant effects on gastrointestinal functions, the possible role of endogenous ET in the host response to mucosal injury has not been well clarified. METHODS The present study describes an investigation of the effects of an endothelin A receptor antagonist, BQ-123, on lactate dehydrogenase (LDH), mucus and albumin flux into the perfusate in a rat model of acute… CONTINUE READING