Endogenous digitalis-like activity in mammalian brain.

  title={Endogenous digitalis-like activity in mammalian brain.},
  author={Mark C Fishman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={76 9},
  • Mark C Fishman
  • Published 1979 in
    Proceedings of the National Academy of Sciences…
A fraction of brain has been prepared that contains a substance mimicking actions of the digitalis glycosides. It both blocks the binding of [3H]ouabain to Na+,K+-ATPase (ATP phosphohydrolase, EC and inhibits the uptake of 86Rb+ into human erythrocytes. Partial isolation was achieved by Sephadex G-10 fractionation and subsequent desalting. This activity is potentially capable of regulating ionic fluxes and concentration gradients across the cell membrane. 

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