Endogenous concentrations of ouabain act as a cofactor to stimulate fluid secretion and cyst growth of in vitro ADPKD models via cAMP and EGFR-Src-MEK pathways.

@article{Jansson2012EndogenousCO,
  title={Endogenous concentrations of ouabain act as a cofactor to stimulate fluid secretion and cyst growth of in vitro ADPKD models via cAMP and EGFR-Src-MEK pathways.},
  author={Kyle Jansson and Anh-Nguyet T Nguyen and Brenda S. Magenheimer and Gail A. Reif and Lavakumar Reddy Aramadhaka and Elsa Bello-Reuss and Darren P Wallace and James P. Calvet and Gustavo Blanco},
  journal={American journal of physiology. Renal physiology},
  year={2012},
  volume={303 7},
  pages={F982-90}
}
In autosomal-dominant polycystic kidney disease (ADPKD), renal cysts develop by aberrant epithelial cell proliferation and transepithelial fluid secretion. We previously showed that ouabain increases proliferation of cultured human ADPKD cells via stimulation of the EGF receptor (EGFR)-Src-MEK/ERK signaling pathway. We examined whether ouabain affects fluid secretion and in vitro cyst growth of human ADPKD cell monolayers, ADPKD cell microcysts cultured in a three-dimensional collagen matrix… CONTINUE READING

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