Endogenous cerebellar neurogenesis in adult mice with progressive ataxia

  title={Endogenous cerebellar neurogenesis in adult mice with progressive ataxia},
  author={Manoj Kumar and Zsolt Csaba and St{\'e}phane Peineau and Rupali Srivastava and Sowmyalakshm{\'i} Rasika and Shyamala Mani and Pierre Gressens and Vincent El Ghouzzi},
  booktitle={Annals of clinical and translational neurology},
OBJECTIVE Transplanting exogenous neuronal progenitors to replace damaged neurons in the adult brain following injury or neurodegenerative disorders and achieve functional amelioration is a realistic goal. However, studies so far have rarely taken into consideration the preexisting inflammation triggered by the disease process that could hamper the effectiveness of transplanted cells. Here, we examined the fate and long-term consequences of human cerebellar granule neuron precursors (GNP… CONTINUE READING
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