Endogenous cardiac glycosides, a new class of steroid hormones.

@article{Schoner2002EndogenousCG,
  title={Endogenous cardiac glycosides, a new class of steroid hormones.},
  author={W. Schoner},
  journal={European journal of biochemistry},
  year={2002},
  volume={269 10},
  pages={2440-8}
}
  • W. Schoner
  • Published 2002 in European journal of biochemistry
The search for endogenous digitalis has led to the isolation of ouabain as well as several additional cardiotonic steroids of the cardenolide and bufadienolide type from blood, adrenals, and hypothalamus. The concentration of endogenous ouabain is elevated in blood upon increased Na(+) uptake, hypoxia, and physical exercise. Changes in blood levels of ouabain upon physical exercise occur rapidly. Adrenal cortical cells in tissue culture release ouabain upon addition of angiotensin II and… CONTINUE READING

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