Endogenous cannabinoid signaling is required for voluntary exercise-induced enhancement of progenitor cell proliferation in the hippocampus.

@article{Hill2010EndogenousCS,
  title={Endogenous cannabinoid signaling is required for voluntary exercise-induced enhancement of progenitor cell proliferation in the hippocampus.},
  author={Matthew Nicholas Hill and Andrea K. Titterness and Anna C. Morrish and Erica J Carrier and Tiffany T-Y Lee and Joana Gil-Mohapel and Boris B. Gorzalka and Cecilia J. Hillard and Brian R Christie},
  journal={Hippocampus},
  year={2010},
  volume={20 4},
  pages={513-23}
}
Voluntary exercise and endogenous cannabinoid activity have independently been shown to regulate hippocampal plasticity. The aim of the current study was to determine whether the endocannabinoid system is regulated by voluntary exercise and if these changes contribute to exercise-induced enhancement of cell proliferation. In Experiment 1, 8 days of free access to a running wheel increased the agonist binding site density of the cannabinoid CB(1) receptor; CB(1) receptor-mediated GTPgammaS… CONTINUE READING