Endogenous calcitonin gene-related peptide (CGRP) mediates adrenergic-dependent vasodilation induced by nicotine in mesenteric resistance arteries of the rat.

@article{Shiraki2000EndogenousCG,
  title={Endogenous calcitonin gene-related peptide (CGRP) mediates adrenergic-dependent vasodilation induced by nicotine in mesenteric resistance arteries of the rat.},
  author={Hirotsugu Shiraki and Hiromu Kawasaki and Satoko Tezuka and Akira Nakatsuma and Yuji Kurosaki},
  journal={British journal of pharmacology},
  year={2000},
  volume={130 5},
  pages={1083-91}
}
1. The mechanisms underlying vasodilator effect of nicotine on mesenteric resistance blood vessels and the role of calcitonin gene-related peptide (CGRP)-containing (CGRPergic) vasodilator nerves were studied in the rat. 2. Mesenteric vascular beds isolated from Wistar rats were perfused with Krebs solution, and perfusion pressure was measured with a pressure transducer. 3. In preparations with intact endothelium and contracted by perfusion with Krebs solution containing methoxamine, perfusion… CONTINUE READING

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