Endogenous bradykinin activates ischaemically sensitive cardiac visceral afferents through kinin B2 receptors in cats.

@article{TjenALooi1998EndogenousBA,
  title={Endogenous bradykinin activates ischaemically sensitive cardiac visceral afferents through kinin B2 receptors in cats.},
  author={Stephanie C Tjen-A-Looi and H L Pan and J C Longhurst},
  journal={The Journal of physiology},
  year={1998},
  volume={510 ( Pt 2)},
  pages={633-41}
}
1. Activity of ischaemically sensitive cardiac visceral afferents during myocardial ischaemia induces both angina and cardiovascular reflexes. Increased production of bradykinin (BK) and cyclo-oxygenase products (i.e. prostaglandins (PGs)) occurs during myocardial ischaemia. However, the role of these agents in activation of ischaemically sensitive cardiac afferents has not been established. The present study tested the hypothesis that BK produced during ischaemia activates cardiac afferents… CONTINUE READING
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