Endogenous ascorbate regenerates vitamin E in the retina directly and in combination with exogenous dihydrolipoic acid.

@article{Stoyanovsky1995EndogenousAR,
  title={Endogenous ascorbate regenerates vitamin E in the retina directly and in combination with exogenous dihydrolipoic acid.},
  author={Detcho A. Stoyanovsky and R. E. Goldman and Ruth M Darrow and D. T. Organisciak and Valerian E Kagan},
  journal={Current eye research},
  year={1995},
  volume={14 3},
  pages={181-9}
}
Vitamin E (alpha-tocopherol) is the major lipid-soluble antioxidant of retinal membranes whose deficiency causes retinal degeneration. Its antioxidant function is realized via scavenging peroxyl radicals as a result of which phenoxyl radicals of alpha-tocopherol are formed. Our hypothesis is that alpha-tocopherol phenoxyl radicals can be reduced by endogenous reductants in the retina, providing for alpha-tocopherol recycling. The results of this study demonstrate for the first time that: (i… CONTINUE READING