Endogenous apolipoprotein A-I stabilizes ATP-binding cassette transporter A1 and modulates Toll-like receptor 4 signaling in human macrophages.

@article{Mogilenko2012EndogenousAA,
  title={Endogenous apolipoprotein A-I stabilizes ATP-binding cassette transporter A1 and modulates Toll-like receptor 4 signaling in human macrophages.},
  author={Denis A. Mogilenko and Sergey V Orlov and Andrey S. Trulioff and Andrey V. Ivanov and Vadim K Nagumanov and Igor V Kudriavtsev and Vladimir S. Shavva and Dmitry A. Tanyanskiy and Andrej P. Perevozchikov},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2012},
  volume={26 5},
  pages={
          2019-30
        }
}
Apolipoprotein A-I (ApoA-I) is the main functional protein component of human high-density lipoproteins. ApoA-I shows various anti-inflammatory and atheroprotective properties toward macrophages; however, endogenous apoA-I expression has not been investigated in macrophages. We have shown that endogenous apoA-I gene is expressed in human macrophages at both mRNA and protein levels. Endogenous ApoA-I is localized in intracellular vesicles and at the external side of the plasma membrane in… CONTINUE READING
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