Endogenous anxiogenic peptide, ODN-diazepam-binding inhibitor, and benzodiazepines enhance the production of interleukin-1 and tumor necrosis factor by human monocytes.

@article{Taupin1991EndogenousAP,
  title={Endogenous anxiogenic peptide, ODN-diazepam-binding inhibitor, and benzodiazepines enhance the production of interleukin-1 and tumor necrosis factor by human monocytes.},
  author={Veronique Taupin and Andr{\'e} Herbelin and B{\'e}atrice Descamps-Latscha and Flora Zavala},
  journal={Lymphokine and cytokine research},
  year={1991},
  volume={10 1-2},
  pages={7-13}
}
Benzodiazepines (BZD) have been described to interact with specific peripheral-type receptors on phagocytes. The present study demonstrates that pico- to nanomolar concentrations of BZD compounds enhance the lipopolysaccharide (LPS)-induced production of tumor necrosis factor (TNF) and interleukin-1 (IL-1) by human monocytes, as determined by specific immunoreactive and biological assays for these cytokines. BZD remained ineffective in the absence of LPS. The activity of BZD was restricted to… CONTINUE READING
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